HIV-1 usually utilizes CCR5 as its coreceptor and rarely switches to a CXCR4-tropic virus until the late stage of infection. CCR5+CD4+ T cells are the major virus-producing cells in viremic individuals as well as SIV-infected nonhuman primates. The differentiation of CCR5+CD4+ T cells is associated with the availability of IL-15, which increases during acute HIV-1 infection. Here, we report that CCR5 was expressed by CD4+ T cells exhibiting effector or effector memory phenotypes with high expression levels of the IL-2/IL-15 receptor common β and γ chains. IL-15, but not IL-7, improved the survival of CCR5+CD4+ T cells, drove their expansion, and facilitated HIV-1 infection in vitro and in humanized mice. Our study suggests that IL-15 plays ...
HIV-1 strains that use CCR5 predominate after transmission and during the asymptomatic period of dis...
CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency viru...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...
Background CD4 T cell depletion during HIV-1 infection is associated with AIDS disease progression, ...
AbstractFunctional immune reconstitution is limited after HAART, maintaining the interest in adjunct...
AbstractCD4+ T cells are critical for effective immune responses against HIV, but they are also the ...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...
Human immunodeficiency virus (HIV) infection is characterized by progressive immunologic dysregulati...
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced dise...
BackgroundWe conducted a phase I clinical trial that infused CCR5 gene-edited CD4+ T cells to determ...
Interleukin-17 (IL-17) is a pro-inflammatory cytokine that is mainly produced by CD4 + T cells. The ...
The chemokine receptor CCR5 is the most important entry coreceptor for HIV-1 in vivo. Its chemokine ...
© 2017 The Author(s). HIV infection affects 37 million people and about 1.7 million are infected ann...
Due to its critical role in NK cell differentiation and CD8(+) T cell homeostasis, the importance of...
AbstractSeveral CCR5 ligands, including small molecules and monoclonal antibodies (MAbs), are being ...
HIV-1 strains that use CCR5 predominate after transmission and during the asymptomatic period of dis...
CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency viru...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...
Background CD4 T cell depletion during HIV-1 infection is associated with AIDS disease progression, ...
AbstractFunctional immune reconstitution is limited after HAART, maintaining the interest in adjunct...
AbstractCD4+ T cells are critical for effective immune responses against HIV, but they are also the ...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...
Human immunodeficiency virus (HIV) infection is characterized by progressive immunologic dysregulati...
CD4(+) T-cell loss is the hallmark of HIV-1 infection. CD4 counts fall more rapidly in advanced dise...
BackgroundWe conducted a phase I clinical trial that infused CCR5 gene-edited CD4+ T cells to determ...
Interleukin-17 (IL-17) is a pro-inflammatory cytokine that is mainly produced by CD4 + T cells. The ...
The chemokine receptor CCR5 is the most important entry coreceptor for HIV-1 in vivo. Its chemokine ...
© 2017 The Author(s). HIV infection affects 37 million people and about 1.7 million are infected ann...
Due to its critical role in NK cell differentiation and CD8(+) T cell homeostasis, the importance of...
AbstractSeveral CCR5 ligands, including small molecules and monoclonal antibodies (MAbs), are being ...
HIV-1 strains that use CCR5 predominate after transmission and during the asymptomatic period of dis...
CD4+ central memory T cells play a critical role in the pathogenesis of simian immunodeficiency viru...
In HIV-1-infected patients, increased numbers of circulating CD8+ T cells are linked to increased ri...