MiToS and King\u27s staging as clinical outcome measures in ALS: A retrospective analysis of the FORTITUDE-ALS trial
- Gebrehiwet, Paulos
- Meng, Lisa
- Rudnicki, Stacy A
- Sarocco, Phil
- Wei, Jenny
- Wolff, Andrew A
- Chiò, Adriano
- Andrews, Jinsy A
- Genge, Angela
- Jackson, Carlayne E
- Lechtzin, Noah
- Miller, Timothy M
- Shefner, Jeremy M
Publication date
May 2023
DOI Publisher
Informa UK Limited Language
EnglishAbstract
OBJECTIVE: To evaluate the Milano-Torino staging (MiToS) and King\u27s staging systems as potential outcome measures for clinical trials in amyotrophic lateral sclerosis (ALS) by assessing these outcomes in FORTITUDE-ALS. METHODS: This was a RESULTS: The full analysis set consisted of 456 patients randomized 3:1 ( CONCLUSION: This exploratory analysis showed the feasibility of MiToS and King\u27s staging as potential outcome measures in ALS. Additional studies of these staging systems are needed to further explore their utility in ALS clinical trials
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