Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication
- Gargaro, Marco
- Briseño, Carlos G
- Bagadia, Prachi
- Durai, Vivek
- Theisen, Derek J
- Kim, Sunkyung
- Colonna, Marco
- Murphy, Theresa L
- Murphy, Kenneth M
- et al.,
DOIAbstract
Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is used by cDCs in maintaining tolerance, but its role in different subsets remains unclear. At homeostasis, only mature CCR
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