Lung cancer is the most common cancer in the world and several miRNAs are associated with it. MiRNA sponges are presented as tools to inhibit miRNAs. We designed a system to capture miRNAs based on circular RNAs (circRNA). To demonstrate its usefulness, we chose miR-21, which is upregulated and implicated in lung cancer. We constructed a miR-21 sponge and inserted it into a vector that facilitates circular RNA production (Circ-21) to study its effect on growth, colony formation, and migration in lung cancer cell lines and multicellular tumor spheroids (MTS). Circ-21 induced a significant and time-dependent decrease in the growth of A549 and LL2 cells, but not in L132 cells. Furthermore, A549 and LL2 cells transfected with Circ-21 showed a l...
MicroRNAs are known to be upregulated or downregulated in various types of cancer, leading to change...
Background: MicroRNAs (miRNAs) function as endogenous regulators of biological behaviors of human ca...
Circular RNAs (circRNA) have been reported to exert evident functions in many human carcinomas. Howe...
Lung cancer is the most common cancer in the world and several miRNAs are associated with it. MiRNA ...
MicroRNA (miR) sponges containing miR binding sequences constitute a potentially powerful molecular ...
Breast cancer is the most common type of cancer in women, with chemotherapy being the main strategy....
Circular RNAs (circRNAs) are single‐stranded RNAs which form a covalently closed continuous loop. Al...
MicroRNAs (miRNAs) are an evolutionarily conserved class of small regulatory noncoding RNAs, binding...
Abstract Background Circular RNA (circRNA) circ_0072088 has been reported to be associated with NSCL...
Breast cancer (BC) and colon cancer (CRC) are the two most deadly cancers in the world. These cancer...
Zhaohui Zhang,1 Hao Hu,2 Qian Li,1 Fumei Yi,1 Yan’e Liu1 1Department of Tumor Chemotherapy and Radia...
Abstract Background Circular RNA (circRNA), as a covalently closed circular RNA molecule, is widely ...
Circular RNAs (circRNAs) are a newly validated class of endogenous non-coding RNA, generated from th...
Background MicroRNAs (miRNAs) are one of the main factors in cancer development and can alter the ac...
Abstract Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However,...
MicroRNAs are known to be upregulated or downregulated in various types of cancer, leading to change...
Background: MicroRNAs (miRNAs) function as endogenous regulators of biological behaviors of human ca...
Circular RNAs (circRNA) have been reported to exert evident functions in many human carcinomas. Howe...
Lung cancer is the most common cancer in the world and several miRNAs are associated with it. MiRNA ...
MicroRNA (miR) sponges containing miR binding sequences constitute a potentially powerful molecular ...
Breast cancer is the most common type of cancer in women, with chemotherapy being the main strategy....
Circular RNAs (circRNAs) are single‐stranded RNAs which form a covalently closed continuous loop. Al...
MicroRNAs (miRNAs) are an evolutionarily conserved class of small regulatory noncoding RNAs, binding...
Abstract Background Circular RNA (circRNA) circ_0072088 has been reported to be associated with NSCL...
Breast cancer (BC) and colon cancer (CRC) are the two most deadly cancers in the world. These cancer...
Zhaohui Zhang,1 Hao Hu,2 Qian Li,1 Fumei Yi,1 Yan’e Liu1 1Department of Tumor Chemotherapy and Radia...
Abstract Background Circular RNA (circRNA), as a covalently closed circular RNA molecule, is widely ...
Circular RNAs (circRNAs) are a newly validated class of endogenous non-coding RNA, generated from th...
Background MicroRNAs (miRNAs) are one of the main factors in cancer development and can alter the ac...
Abstract Circular RNAs are widely expressed in eukaryotic cells and associated with cancer. However,...
MicroRNAs are known to be upregulated or downregulated in various types of cancer, leading to change...
Background: MicroRNAs (miRNAs) function as endogenous regulators of biological behaviors of human ca...
Circular RNAs (circRNA) have been reported to exert evident functions in many human carcinomas. Howe...