Tau pathology is a hallmark of Alzheimer’s disease (AD) and other tauopathies, but how pathological tau accumulation alters the glutamate receptor dynamics driving synaptic dysfunction is unclear. Here, we determined the impact of tau pathology on AMPAR expression, density, and subcellular distribution in the hippocampus of P301S mice using immunoblot, histoblot, and quantitative SDS-digested freeze-fracture replica labeling (SDS-FRL). Histoblot and immunoblot showed differential regulation of GluA1 and GluA2 in the hippocampus of P301S mice. The GluA2 subunit was downregulated in the hippocampus at 3 months while both GluA1 and GluA2 subunits were downregulated at 10 months. However, the total amount of GluA1-4 was similar in P301S mice an...
Using synaptosomes purified from the brains of two transgenic mouse models overexpressing mutated hu...
[eng] The neuropathological hallmarks of Alzheimer’s disease are senile plaques, extracellular depos...
<div><p>Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest...
Tau pathology is a hallmark of Alzheimer's disease (AD) and other tauopathies, but how pathological ...
Individuals at risk of developing Alzheimer’s disease (AD) often exhibit hippocampal hyperexcitabili...
Using synaptosomes purified from the brains of two transgenic mouse models overexpressing mutated hu...
Intracellular tau aggregates are the neuropathological hallmark of several neurodegenerative disease...
Despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the ...
Intracellular tau aggregates are the neuropathological hallmark of several neurodegenerative disease...
SummaryNeurofibrillary tangles advance from layer II of the entorhinal cortex (EC-II) toward limbic ...
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and deme...
Individuals at risk for developing Alzheimer\u27s disease (AD) often exhibit neuronal network hypere...
Our previous research demonstrated that soluble amyloid-β (Aβ)42, elicits presynaptic glutamate rele...
The exposure to high glucocorticoids (GC) triggers neuronal atrophy and cognitive deficits, but the ...
The aim of this PhD-thesis was to characterize single and double transgenic mouse models for Alzheim...
Using synaptosomes purified from the brains of two transgenic mouse models overexpressing mutated hu...
[eng] The neuropathological hallmarks of Alzheimer’s disease are senile plaques, extracellular depos...
<div><p>Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest...
Tau pathology is a hallmark of Alzheimer's disease (AD) and other tauopathies, but how pathological ...
Individuals at risk of developing Alzheimer’s disease (AD) often exhibit hippocampal hyperexcitabili...
Using synaptosomes purified from the brains of two transgenic mouse models overexpressing mutated hu...
Intracellular tau aggregates are the neuropathological hallmark of several neurodegenerative disease...
Despite the well-accepted role of the two main neuropathological markers (β-amyloid and tau) in the ...
Intracellular tau aggregates are the neuropathological hallmark of several neurodegenerative disease...
SummaryNeurofibrillary tangles advance from layer II of the entorhinal cortex (EC-II) toward limbic ...
Tau pathology is highly related to synaptic and neuronal loss, leading to cognitive decline and deme...
Individuals at risk for developing Alzheimer\u27s disease (AD) often exhibit neuronal network hypere...
Our previous research demonstrated that soluble amyloid-β (Aβ)42, elicits presynaptic glutamate rele...
The exposure to high glucocorticoids (GC) triggers neuronal atrophy and cognitive deficits, but the ...
The aim of this PhD-thesis was to characterize single and double transgenic mouse models for Alzheim...
Using synaptosomes purified from the brains of two transgenic mouse models overexpressing mutated hu...
[eng] The neuropathological hallmarks of Alzheimer’s disease are senile plaques, extracellular depos...
<div><p>Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is one of the earliest...