Analysis of Ribosomes During Develpment of Chick Liver and Muscle

Studies made in recent years on protein synthesis have indicated a very intricate process in which the ribosome plays an active role. From these studies it has been sug­gested that control of specific protein synthesis in eukaryotes during organogenesis may be exerted in part at the level of the ribosome. The present thesis reports on research aimed at contributing to an evaluation of this possibility and to providing a better understanding of the role of ribosomes in embryonic differentiation generally. Following suggestions by my advisor, Dr. Brian Unsworth, a series of experiments have been undertaken to determine whether tis­sue-specific and/or stage-specific ribosomal properties occur during the process of development