Improving signal stability in a multi-electrode array (MEA) system for cardiac biopsies

This work evaluates the performance of a microelectrode array (MEA) to be used in a specific platform dedicated for measuring field potentials of small human cardiac samples. A test bench has been developed to characterize the electrodes by measuring their impedance as well as to modify their characteristic curve using a replatinization process, where black platinum is deposited on the indicated areas of the MEA flex-pcb. This set-up consists of the array of microelectrodes made of gold, together with its corresponding electronic adapter board, a potentiostat and an electrochemical interface. Phosphate buffered saline (PBS), which is commonly considered for this type of analysis, has been used for impedance characterization. Initially, the impedance presents a highly variable behavior at different frequencies as well as between the different channels of the array. Once the platinization process has been carried out, the impedance in all the recording channels is very similar and has decreased over a large part of the frequency range under study. A complete electrical model of the electrodes has been proposed and analyzed, achieving better results by including the mathematical constant phase element (CPE) associated with capacitive behavior (model fitting error < 2%). Finally, the characterization of the different noise contributions has been carried out. Based on the obtained results, it can be concluded that the evaluated system allows the recording of field potential signals from small human cardiac tissues