Additional file 1 of A closed-loop ventilation mode that targets the lowest work and force of breathing reduces the transpulmonary driving pressure in patients with moderate-to-severe ARDS

Additional file 1: Table S1. List of significant pairwise comparisons per time point, significance was determined at a P value < 0.003. Table S2. Specification of the generalized linear mixed model analysis. Figure S1. Line plots showing the mean changes and individual changes over time of transpulmonary ΔP, VT and RR during the two study blocks of the two ventilation modes in the study. Figure S2. CRS vs. VT between closed-loop ventilation and conventional ventilation, and transpulmonary ΔP vs. VT between closed-loop ventilation and conventional ventilation. A negative value means that the parameter decreased with closed-loop ventilation, and a higher value means that the parameter increased with closed-loop ventilation. All dots represent the mean value of an individual patient. Figure S3. Scatterplots of CRS vs. VT and transpulmonary ΔP vs. VT with closed-loop ventilation and conventional ventilation. Each dot was characterized by a single data point. Figure S4. Showing individual patient data of the effect of the change of the ventilation mode on PEEP setting. Figure S5. Showing transpulmonary ΔP per patient during every time point, with closed-loop ventilation and conventional ventilation. The head with number represents the corresponding patient, the x-axis represent the 16 time points per block. Figure S6. Showing PEEP per patient during every time point, with closed-loop ventilation and conventional ventilation. The head with number represents the corresponding patient, the x-axis represent the 16 time points per block. Figure S7. Showing the tidal volumeper patient during every time point, with closed-loop ventilation and conventional ventilation. The head with number represents the corresponding patient, the x-axis represent the 16 time points per block. Figure S8. Showing the respiratory rateper patient during every time point, with closed-loop ventilation and conventional ventilation. The head with number represents the corresponding patient, the x-axis represent the 16 time points per block. Figure S9. Violin plot of pairwise comparisons at individual time points of ΔP. Figure S10. Violin plot of pairwise comparisons at individual time points of transpulmonary ΔP. Figure S11. Violin plot of pairwise comparisons at individual time points of RR. Figure S12. Violin plot of pairwise comparisons at individual time points of MP. Figure S13. Violin plot of pairwise comparisons at individual time points of transpulmonary MP