Background: Doxorubicin (DOX) is among the most widely employed antitumor agents, although its clinical applications have been largely hindered by severe cardiotoxicity. Earlier studies described an essential role of mitochondrial injury in the pathogenesis of DOX cardiomyopathy. PHB2 (Prohibitin 2) is perceived as an essential regulator for mitochondrial dynamics and oxidative phosphorylation (OXPHOS) although its involvement in DOX cardiomyopathy remains elusive. Methods: To decipher the possible role of PHB2 in DOX cardiomyopathy, tamoxifen-induced cardiac-specific PHB2 conditional knockout mice were generated and subjected to DOX challenge. Cardiac function and mitochondrial profiles were examined. Screening of downstream mediators of P...
Doxorubicin (DOX)-induced cardiotoxicity is thought to be mediated by the generation of superoxide a...
Doxorubicin (DOX) is an effective chemotherapeutic agent that plays an unparalleled role in cancer t...
Doxorubicin (DOX) is an extensively used chemotherapeutic agent that can cause severe and frequent c...
Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the Un...
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are pr...
The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavag...
Background In sepsis, circulating cytokines and lipopolysaccharide elicit mitochondrial dysfunction ...
Aims:Doxorubicin cardiomyopathy is a lethal pathology characterized by oxidative stress, mitochondri...
The cardiac toxicity of doxorubicin (DOX), a potent anticancer anthracycline antibiotic, is believed...
Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell surv...
artical,12pagesThe clinical utility of anthracycline anticancer agents, especially doxorubicin, is l...
Aims The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. F...
AbstractDoxorubicin (DOX)-induced cardiotoxicity is thought to be mediated by the generation of supe...
The clinical utility of anthracycline anticancer agents, especially doxorubicin, is limited by a pro...
The anticancer therapy of doxorubicin (Dox) has been limited by its acute and chronic cardiotoxicity...
Doxorubicin (DOX)-induced cardiotoxicity is thought to be mediated by the generation of superoxide a...
Doxorubicin (DOX) is an effective chemotherapeutic agent that plays an unparalleled role in cancer t...
Doxorubicin (DOX) is an extensively used chemotherapeutic agent that can cause severe and frequent c...
Sepsis results in more than 200,000 deaths annually and is the 10th leading cause of death in the Un...
Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are ubiquitously expressed, and are pr...
The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. Flavag...
Background In sepsis, circulating cytokines and lipopolysaccharide elicit mitochondrial dysfunction ...
Aims:Doxorubicin cardiomyopathy is a lethal pathology characterized by oxidative stress, mitochondri...
The cardiac toxicity of doxorubicin (DOX), a potent anticancer anthracycline antibiotic, is believed...
Prohibitins (PHBs) are scaffold proteins that modulate many signaling pathways controlling cell surv...
artical,12pagesThe clinical utility of anthracycline anticancer agents, especially doxorubicin, is l...
Aims The clinical use of doxorubicin for the treatment of cancer is limited by its cardiotoxicity. F...
AbstractDoxorubicin (DOX)-induced cardiotoxicity is thought to be mediated by the generation of supe...
The clinical utility of anthracycline anticancer agents, especially doxorubicin, is limited by a pro...
The anticancer therapy of doxorubicin (Dox) has been limited by its acute and chronic cardiotoxicity...
Doxorubicin (DOX)-induced cardiotoxicity is thought to be mediated by the generation of superoxide a...
Doxorubicin (DOX) is an effective chemotherapeutic agent that plays an unparalleled role in cancer t...
Doxorubicin (DOX) is an extensively used chemotherapeutic agent that can cause severe and frequent c...