The origins of proof-theoretic semantics lie in the question of what constitutes the meaning of the logical connectives and its response: the rules of inference that govern the use of the connective. However, what if we go a step further and ask about the meaning of a proof as a whole? In this paper we address this question and lay out a framework to distinguish sense and denotation of proofs. Two questions are central here. First of all, if we have two (syntactically) different derivations, does this always lead to a difference, firstly, in sense, and secondly, in denotation? The other question is about the relation between different kinds of proof systems (here: natural deduction vs. sequent calculi) with respect to this distinction. Do t...