Features of the clinical course of osteoarthritis in combination with hypertension

Osteoarthritis is a prevalent and costly debilitating condition that affects 240 million people worldwide. Osteoarthritis is a whole-joint disorder, not only involving articular cartilage degradation but also subchondral bone disturbance, synovitis, etc. Osteoarthritis afflicts both load-bearing (knee and hip) and non-load-bearing joints (hand). About half of patients with osteoarthritis have additional five or more comorbidities. Some significant factors in the development and advance of osteoarthritis are diabetes and obesity, which are a cluster of four cardiometabolic risk factors, obesity, along with aging and injury