Additional file 2: Figure S2. Comparison between E-GWAS strategy and BSLMM, MLMM, mrMLM, BLINK, or FarmCPU under different numbers of QTN with a heritability of 0.2 and 0.8. The comparisons were conducted between different simulated scenarios. The numbers of true and false positives among 100 replicates were recorded. Phenotypes were simulated based on the real genotypes of 4555 individuals and 41,078 SNPs with different numbers of QTN (m = 20, 100, 500 and 1000) and different levels of heritability (h2 = 0.2, 0.8). Line charts a, b illustrate the numbers of true QTN detected and the rate of false positive variants, respectively. BSLMM, MLMM, mrMLM, BLINK, FarmCPU, and E-GWAS are represented by different colors, as shown in the legend
1. With increasing application of pooled-sequencing approaches to population genomics robust methods...
False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed e...
The name of the candidate gene and the method—mutant (KO), RNAi (KD), or Mendelian Randomization (MR...
Additional file 1: Figure S1. Comparison between E-GWAS strategy and BSLMM, MLMM, mrMLM, BLINK, or F...
Additional file 3: Figure S3. Comparison of the proportions of false QTN that were located in the di...
Additional file 4: Figure S4. Performance of E-GWAS at different sizes of the bin. a, b Numbers of t...
Additional file 5: Figure S5. Phenotypic distribution for backfat thickness. The Kolmogorov–Smirnov ...
Additional file 6: Figure S6. Linkage disequilibrium block plots of four SNPs from the E-GWAS result...
Additional file 1. For simulated SNP data with a genetic correlation of 0.9, the number of true posi...
<p>This table presents the number of positive detection via associated markers of each simulated QTL...
1.5 million variants were simulated with z-scores for four traits with 10% of variants as truly asso...
We simulated phenotypes with varying case/control ratio—(a) 1625/1625, (b) 1625/3250, (c) 1625/4875 ...
<p>(A) Current approach. GWAS identify variants that are overrepresented in cases. Rare variants of ...
Additional file 1: Supplemental figure 1. Frequency distribution of 6 kernel colour traits under two...
Power (PO) and false positives rate (FPR) with 25 QTL and 25 % missing rate, for major and minor QTL...
1. With increasing application of pooled-sequencing approaches to population genomics robust methods...
False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed e...
The name of the candidate gene and the method—mutant (KO), RNAi (KD), or Mendelian Randomization (MR...
Additional file 1: Figure S1. Comparison between E-GWAS strategy and BSLMM, MLMM, mrMLM, BLINK, or F...
Additional file 3: Figure S3. Comparison of the proportions of false QTN that were located in the di...
Additional file 4: Figure S4. Performance of E-GWAS at different sizes of the bin. a, b Numbers of t...
Additional file 5: Figure S5. Phenotypic distribution for backfat thickness. The Kolmogorov–Smirnov ...
Additional file 6: Figure S6. Linkage disequilibrium block plots of four SNPs from the E-GWAS result...
Additional file 1. For simulated SNP data with a genetic correlation of 0.9, the number of true posi...
<p>This table presents the number of positive detection via associated markers of each simulated QTL...
1.5 million variants were simulated with z-scores for four traits with 10% of variants as truly asso...
We simulated phenotypes with varying case/control ratio—(a) 1625/1625, (b) 1625/3250, (c) 1625/4875 ...
<p>(A) Current approach. GWAS identify variants that are overrepresented in cases. Rare variants of ...
Additional file 1: Supplemental figure 1. Frequency distribution of 6 kernel colour traits under two...
Power (PO) and false positives rate (FPR) with 25 QTL and 25 % missing rate, for major and minor QTL...
1. With increasing application of pooled-sequencing approaches to population genomics robust methods...
False positives in a Genome-Wide Association Study (GWAS) can be effectively controlled by a fixed e...
The name of the candidate gene and the method—mutant (KO), RNAi (KD), or Mendelian Randomization (MR...