Overexpression of USP12 in THP-1-Mφs promoted the anti-virus response.
- Yuling Fu (2275756)
- Xiaoxia Zhan (5676113)
- Xiaolong You (8196798)
- Dingnai Nie (16503360)
- Haiyan Mai (16503363)
- Yitian Chen (422264)
- Shitong He (16503366)
- Junli Sheng (16503369)
- Zhijie Zeng (6455483)
- Hongwei Li (17402)
- Jinlong Li (388896)
- Shengfeng Hu (4887049)
Publication date
July 2023
DOI Publisher
Public Library of Science (PLoS)Abstract
THP-1-Mφs transfected with transfected with control or expression vector for USP12 were infected with VSV and HSV virus for 24 hours. Production of IFN-β, CCL5 and IL-6 was determined by ELISA after VSV infection (A) or HSV-1 infection (B). QPCR was performed to analyze the expression of ISG15 and MX1 after VSV (C) and HSV (D) infection. (E) Viral VSV-N RNA (left) and HSP-1-V16 RNA (right) were determined by qPCR at 12 hours and 24 hours after infection. (F) Viral titres assay of VSV or HSV-1 were determined at 12 hours and 24 hours after infection. Data shown are the mean ±SD. *P P P (TIF)</p
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