The associations of glycosylated hemoglobin with grey matter volume and depression: Investigating mediating role of grey matter volume
- Dashan Zheng
- Miao Cai
- Zhengmin (Min) Qian
- Chongjian Wang
- Shiyu Zhang
- Zilong Zhang
- Xiaojie Wang
- Michael G. Vaughn
- Elizabeth Bingheim
- Hualiang Lin
DOIAbstract
Background: Depression has caused enormous health burden to human worldwide. Glycemia has been found as one important risk factor of depression. However, the biological mechanism underlying this relationship remained largely unknown. Methods: This analysis was derived from a cohort of 33,151 participants in the UK Biobank who provided brain magnetic resonance imaging data from 2014 to 2020. Participants were classified into diabetic, prediabetic and non-diabetic groups, as well as groups aged ≥60 years and <60 years. We assessed the associations between glycosylated hemoglobin (HbA1c), grey matter volume (GMV) in 117 brain regions, and depression based on the multivariable linear and logistic regression. We further investigated the mediatio...
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