We investigate anomalies in the class of non-local field theories that have been proposed as an ultraviolet completion of 4-D Quantum Field Theory (QFT) with generalizing the kinetic energy operators to an infinite series of higher derivatives inspired by string field theory and ghost-free non-local approaches to quantum gravity. We explicitly calculate the vector and chiral anomalies in a string-inspired non-local extension of QED. We show that the vector anomaly vanishes as required by gauge-invariance and the Ward identity. On the other hand, although the chiral anomaly vanishes to the leading order with massless fermions, it nonetheless does not vanish with the massive fermions and we calculate it to the leading order in scale of non-lo...