In experiments with yeast strain MP1, co-carcinogens were found to be co-mutagenic and antirecombinogenic, tumor promoters to be co-recombinogenic and antimutagenic. Substances that were co-carcinogens as well as tumor promoters had an intermediary effect. Bile acids showed all three possible ways of action supporting the hypothesis that mutagenesis is the mechanism by which chemicals induce malignancy, and that co-carcinogens modify the process by enhancement of mutagenicity, whereas tumor promoters effect carcinogenesis by increase of the spontaneous frequency of recombination. These results were confirmed in the mammalian spot test, by in vivo treatment of mice with the following: (a) the co-carcinogens catechol and hydroquinone, (b) the...
Genetic recombination systems are present in all living cells and viruses and generally contribute t...
To study the interactions between chemical carcinogens and oncogenic retroviruses, BALB/Mo mice whic...
Although physical injury was the first type of tumor promoter to be described (1) and croton oil wit...
The approach of this work was to investigate the influence of tumor promoters and co-carcinogens upo...
Previously, it has been shown that parallels exist between the effects of tumour promoters and co-ca...
In recent experiments with yeast strain MP1, cocarcinogens were found to be comutagenic and antireco...
Carcinogens are generally classified into two groups: genotoxic and non-genotoxic. As the final prod...
In experiments using yeast without an external metabolic activation system, the hormones testosteron...
When Saccharomyces cerevisia MP1 was treated with bile acids alone or in combination with triethylen...
To understand molecular mechanisms of the mutation fixation process induced by a mutagen and carcino...
Results are reported from studies that showed that mutagenesis of mammalian cells can be achieved by...
12-O-Tetradecanoylphorbol 13-acetate (TPA), a powerful tumor promoter, is shown to induce sister chr...
ABSTRACT-Mutagenic potential of 1,2-dimethylhydrazlne (DMH) was Investigated in the host-mediated as...
bolically activated benzo[a]pyrene [B(a)P] and its proximate carcinogenic metabolite, (+)trans 7,8-d...
The mammalian spot test is suitable for detecting gene mutations and reciprocal recombinations. When...
Genetic recombination systems are present in all living cells and viruses and generally contribute t...
To study the interactions between chemical carcinogens and oncogenic retroviruses, BALB/Mo mice whic...
Although physical injury was the first type of tumor promoter to be described (1) and croton oil wit...
The approach of this work was to investigate the influence of tumor promoters and co-carcinogens upo...
Previously, it has been shown that parallels exist between the effects of tumour promoters and co-ca...
In recent experiments with yeast strain MP1, cocarcinogens were found to be comutagenic and antireco...
Carcinogens are generally classified into two groups: genotoxic and non-genotoxic. As the final prod...
In experiments using yeast without an external metabolic activation system, the hormones testosteron...
When Saccharomyces cerevisia MP1 was treated with bile acids alone or in combination with triethylen...
To understand molecular mechanisms of the mutation fixation process induced by a mutagen and carcino...
Results are reported from studies that showed that mutagenesis of mammalian cells can be achieved by...
12-O-Tetradecanoylphorbol 13-acetate (TPA), a powerful tumor promoter, is shown to induce sister chr...
ABSTRACT-Mutagenic potential of 1,2-dimethylhydrazlne (DMH) was Investigated in the host-mediated as...
bolically activated benzo[a]pyrene [B(a)P] and its proximate carcinogenic metabolite, (+)trans 7,8-d...
The mammalian spot test is suitable for detecting gene mutations and reciprocal recombinations. When...
Genetic recombination systems are present in all living cells and viruses and generally contribute t...
To study the interactions between chemical carcinogens and oncogenic retroviruses, BALB/Mo mice whic...
Although physical injury was the first type of tumor promoter to be described (1) and croton oil wit...