A series of overlapping deletions in chromosome 7 (C7) of the mouse at and in the proximity of the albino locus (c) have been shown to cause failure of expression of various hepatocyte-specific genes in newborn lethal deletion homozygotes including TAT, PepCK, SDH, glucose-6-phosphatase, P450, cytochione etc. (Gluecksohn-Waelsch, Cell 16: 225-237 (1979)). More recent work has suggested that sequences corresponding to the deletions encode trans-acting factor(s) involved in the transcriptional control of such genes, which map on other chromosomes. The smallest deletion, c high 14CoS, used in our studies, comprises about 1.5 cM. In attempts to characterize DNA sequences involved in the regulation of such genes, a microclone library enriched fo...
grantor: University of TorontoGenomic imprinting is a fascinating biological phenomenon th...
A mouse 7S RNA cDNA plasmid clone was employed to identify and map DNA restriction fragment variants...
SummaryRadiation induced chromosomal deletions at the albino locus in the mouse, lethal when homozyg...
Primary liver cultures of newborn albino deletion mutant mice lacing about 1.5 Kb on chromosome 7 at...
Chromosome deletions have several applications in the genetic analysis of complex organisms. They ca...
<p>(<b>A</b>) Quantitative PCR analysis of <i>Chd7</i> exons 1, 2, 3, 4, 6, 18, and 38 on chromosome...
As the genetic and physical mapping stage of the Human Genome Project nears completion, the focus is...
Chromosome deletion complexes in model organisms serve as valuable genetic tools for the functional ...
We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examini...
Human minisatellite probes cross-hybridize to mouse DNA and detect multiple variable loci. The resul...
Chromosomal deletions (deficiencies\u27) are powerful tools in the genetic analysis of complex genom...
Murine mucopolysaccharidosis type VII is a heritable disease caused by a spontaneous mutation, gus(m...
Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentati...
Analysis of mouse specific-locus (SL) mutations at three loci has identified over 33 distinct comple...
Two mouse YACs, PA-2 and PA-3, contain the Xist gene and are 460 kb and 3.3 Mb long respectively. Wh...
grantor: University of TorontoGenomic imprinting is a fascinating biological phenomenon th...
A mouse 7S RNA cDNA plasmid clone was employed to identify and map DNA restriction fragment variants...
SummaryRadiation induced chromosomal deletions at the albino locus in the mouse, lethal when homozyg...
Primary liver cultures of newborn albino deletion mutant mice lacing about 1.5 Kb on chromosome 7 at...
Chromosome deletions have several applications in the genetic analysis of complex organisms. They ca...
<p>(<b>A</b>) Quantitative PCR analysis of <i>Chd7</i> exons 1, 2, 3, 4, 6, 18, and 38 on chromosome...
As the genetic and physical mapping stage of the Human Genome Project nears completion, the focus is...
Chromosome deletion complexes in model organisms serve as valuable genetic tools for the functional ...
We investigated the genetic organization and evolutionary origin of t chromosomes of mice by examini...
Human minisatellite probes cross-hybridize to mouse DNA and detect multiple variable loci. The resul...
Chromosomal deletions (deficiencies\u27) are powerful tools in the genetic analysis of complex genom...
Murine mucopolysaccharidosis type VII is a heritable disease caused by a spontaneous mutation, gus(m...
Recessive mutant alleles at the pink-eyed dilution (p) locus on mouse chromosome 7 reduce pigmentati...
Analysis of mouse specific-locus (SL) mutations at three loci has identified over 33 distinct comple...
Two mouse YACs, PA-2 and PA-3, contain the Xist gene and are 460 kb and 3.3 Mb long respectively. Wh...
grantor: University of TorontoGenomic imprinting is a fascinating biological phenomenon th...
A mouse 7S RNA cDNA plasmid clone was employed to identify and map DNA restriction fragment variants...
SummaryRadiation induced chromosomal deletions at the albino locus in the mouse, lethal when homozyg...