Hematological, biochemical, and histological alteration induced by nano silver material on male rats

This study investigates the effects of I/P injection of nano silver materials in the dose 0.2, 0.4, 0.6 mg/kg B.W. for 21 days on blood parameters, cardiac and hepatic tissue histology, and their functions. The results showed a significant increase in the blood parameters of treated animals in compared with the control group. The histological study showed that the histological alteration is more pronounced in the animals that treated with the dose 0.6 mg/kg B.W. which is characterized by inflammatory reaction with degeneration and necrosis of hepatocytes. In contrast, the histological alteration of cardiac muscle showed generalized congestion of blood capillaries, degeneration, and necrosis of cardiomyocytes with inflammatory reaction. Our conclusion of this study showed that the nano silver materials have a pronounced cytotoxic impact on the histological structure and function of the liver and heart besides the influence on the blood parameters (RBCs, platelets, hemoglobin, WBCs, MCV, MCH, MCHC)