Male and female F-344 rats were exposed 6hr/day, 5 days/week for up to 24 months to a special test toner at 0, 1, 4 and 16 mg/mhigh3 by the inhalation route. 59Fe-labeled iron oxide and 85Sr-labeled polystyrene particles were periodically inhaled by the nose only route and used to measure alveolar clearance rates during the course of the study. The final pulmonary burdens of toner at the three exposure levels were 0,22, 1,73, and 15,6 mg/lung, respectively. Alveolar clearance of both tracers was substantially impaired at the toner high-exposure level, and moderately slowed at the toner middle-exposure level
In previous inhalation studies, an impairment of the alveolar clearance in rats was observed, follow...
The ability of the lung to mechanically remove inhaled deposited particles is an important mammalian...
The ability of the lung to mechanically remove inhaled deposited particles is an important mammalian...
Male and female F-344 rats were exposed 6 hrs/day 5 days/week for up to 24-months to a special test ...
A subchronic inhalation study, using SPF, F-344 rats, was conducted for 6 hr/da, 5 da/wk for 13 week...
In a chronic study of a test toner in F-344 rats an impairment of alveolar clearance and increased t...
A chronic inhalation study of a test toner was conducted by exposure of groups of F-344 rats for 6 h...
We have defined the Maximum Functionally Tolerated Dose (MFTD) of a material as the lung burden for ...
A chronic inhalation study of a test toner was conducted by exposure of groups of F-344 rats for 6hr...
The objective of this study was to investigate whether the effects of dust overload are reversible u...
Cigarette smoking can influence the pulmonary disposition of other inhaled materials in humans and l...
For particles which show low solubility and/or slight biological effects a general threshold limit i...
Pulmonary function measurements using the whole body plethysmograph were performed in rats exposed b...
Male and female Syrian golden hamsters were exposed 6h/day, 5 days/wk for up to 18 month to a specia...
Rats and hamsters inhaled different mineral dusts (TiO2, fly ash from coal fired power plants, man m...
In previous inhalation studies, an impairment of the alveolar clearance in rats was observed, follow...
The ability of the lung to mechanically remove inhaled deposited particles is an important mammalian...
The ability of the lung to mechanically remove inhaled deposited particles is an important mammalian...
Male and female F-344 rats were exposed 6 hrs/day 5 days/week for up to 24-months to a special test ...
A subchronic inhalation study, using SPF, F-344 rats, was conducted for 6 hr/da, 5 da/wk for 13 week...
In a chronic study of a test toner in F-344 rats an impairment of alveolar clearance and increased t...
A chronic inhalation study of a test toner was conducted by exposure of groups of F-344 rats for 6 h...
We have defined the Maximum Functionally Tolerated Dose (MFTD) of a material as the lung burden for ...
A chronic inhalation study of a test toner was conducted by exposure of groups of F-344 rats for 6hr...
The objective of this study was to investigate whether the effects of dust overload are reversible u...
Cigarette smoking can influence the pulmonary disposition of other inhaled materials in humans and l...
For particles which show low solubility and/or slight biological effects a general threshold limit i...
Pulmonary function measurements using the whole body plethysmograph were performed in rats exposed b...
Male and female Syrian golden hamsters were exposed 6h/day, 5 days/wk for up to 18 month to a specia...
Rats and hamsters inhaled different mineral dusts (TiO2, fly ash from coal fired power plants, man m...
In previous inhalation studies, an impairment of the alveolar clearance in rats was observed, follow...
The ability of the lung to mechanically remove inhaled deposited particles is an important mammalian...
The ability of the lung to mechanically remove inhaled deposited particles is an important mammalian...