Some major results: Lung tumors occured in rats after exposure to DE, CB and TiO2 and the tumor rate increased with increasing normalized exposure concentrations independent of the kind of particle inhaled. No lung tumors were found after exposure to 0.8 mg/m3 diesel soot but, one lung tumor-bearing rat occured in controls. Alveolar lung clearance was significantly impaired already after 3 months of exposure to 0.8 mg/m3 diesel soot; at this time the lung contained 0.6 mg diesel soot. This amount increased to 6 mg after 24 months whereas the exposure to 7.5 mg/m3 diesel soot led to a lung particle load of 60 mg. Despite higher exposure concentrations of CB and TiO2 compared to diesel soot, CB and TiO2-exposed lung contained about 20 mg less...
The objective of this study was to evaluate the toxicity of inhaled diesel engine–generated fine car...
Exposure to high concentrations of carbon black (Cb) produces lung tumors in rats, but not mice or h...
Carbon black (CB) particles almost completely devoid of organic compounds (Printex 90, Degussa), PAH...
Wistar rats were exposed for 2 yr to diesel engine exhaust, carbon black, and ultrafine TiO2 and wer...
Female Wistar rats were exposed 19 hrs/day, 5 days/wk for 24 months to diesel exhaust at particle co...
The co-carcinogenic effect of intratracheally (i.tr.) administered nuisance particulates like titani...
The co-carcinogenic effect of intratracheally (i.tr.) administered nuisance particulates like titani...
Differences among laboratory animal species in the pulmonary carcinogenicity of chronic inhalation e...
Exposure of rats to diesel emissions results in the development of lung tumors. The objective of thi...
diesel exhaust on the bronchoalveolar region of the respiratory tract of rodents was assessed by ser...
Hamsters, mice and rats were used for long-term inhalation exposures to approximately maximum tolera...
Ultrafine particles (...) showed an exposure concentration-dependent increase of the lung tumor rate...
Ultrafine carbon black, diesel exhaust soot, and titanium dioxide are carcinogenic at sufficient exp...
Intratracheal instillation of several non-fibrous dusts induced tumour rates of between 3 and 65 per...
To study the subchronic and chronic lung effects of low dose of Diesel Exhaust Particles (DEPs), mic...
The objective of this study was to evaluate the toxicity of inhaled diesel engine–generated fine car...
Exposure to high concentrations of carbon black (Cb) produces lung tumors in rats, but not mice or h...
Carbon black (CB) particles almost completely devoid of organic compounds (Printex 90, Degussa), PAH...
Wistar rats were exposed for 2 yr to diesel engine exhaust, carbon black, and ultrafine TiO2 and wer...
Female Wistar rats were exposed 19 hrs/day, 5 days/wk for 24 months to diesel exhaust at particle co...
The co-carcinogenic effect of intratracheally (i.tr.) administered nuisance particulates like titani...
The co-carcinogenic effect of intratracheally (i.tr.) administered nuisance particulates like titani...
Differences among laboratory animal species in the pulmonary carcinogenicity of chronic inhalation e...
Exposure of rats to diesel emissions results in the development of lung tumors. The objective of thi...
diesel exhaust on the bronchoalveolar region of the respiratory tract of rodents was assessed by ser...
Hamsters, mice and rats were used for long-term inhalation exposures to approximately maximum tolera...
Ultrafine particles (...) showed an exposure concentration-dependent increase of the lung tumor rate...
Ultrafine carbon black, diesel exhaust soot, and titanium dioxide are carcinogenic at sufficient exp...
Intratracheal instillation of several non-fibrous dusts induced tumour rates of between 3 and 65 per...
To study the subchronic and chronic lung effects of low dose of Diesel Exhaust Particles (DEPs), mic...
The objective of this study was to evaluate the toxicity of inhaled diesel engine–generated fine car...
Exposure to high concentrations of carbon black (Cb) produces lung tumors in rats, but not mice or h...
Carbon black (CB) particles almost completely devoid of organic compounds (Printex 90, Degussa), PAH...