E-cadherin functions as suppressor of invasion in epithelial cells and its loss is described in many invasive carcinomas. In some tumours, the disappearance of E-cadherin has been correlated with upregulation of other classical cadherins, such as N- or P-cadherin. To analyse the different cellular functions of cadherin molecules, we stably expressed E-cadherin or N-cadherin in the E- and N-cadherin-deficient pancreatic tumour cell line MIA PaCa-2. Only E-cadherin was able to induce a mesenchymal-epithelial transition and suppressed invasion of MIA PaCa-2 cells. Furthermore, only re-expression of E-cadherin resulted in an upregulation of alpha- and beta-catenin mRNAs and protein concentrations. Ectopically expressed N-cadherin failed to asse...
In vitro methods have shown that cancer invasion results from the balance of activation and inactiva...
E-cadherin is crucial to the intercellular adherens junctions which are involved in the organisation...
textabstractThe E-cadherin-catenin complex plays a crucial role in epithelial cell-cell adhesion and...
The extraordinary high number of metastases in pancreatic cancer prompted us to analyse the relevanc...
<div><p>P120-catenin (p120ctn) exerts important roles in regulating E-cadherin and invasiveness in c...
The binding of p120-catenin and β-catenin to the cytoplasmic domain of E-cadherin establishes epithe...
The binding of p120-catenin and β-catenin to the cytoplasmic domain of E-cadherin establishes epithe...
P-cadherin overexpression is associated with worse breast cancer survival, being a poor prognostic m...
The epithelial mesenchymal transition (EMT) is an important process in tumor development. Despite pr...
The cadherin/catenin complex plays a key role in the initiation of cell- cell recognition, and adhes...
Adherens junctions consist of transmembrane cadherins, which interact intracellularly with p120ctn, ...
p120-catenin is considered to be a tumor suppressor because it stabilizes E-cadherin levels at the c...
E-cadherin is a cell-cell adhesion protein fulfilling a prominent role in epithelial differentiation...
Down-regulation of the epithelial cell-cell adhesion molecule E-cadherin is frequently associated wi...
E-cadherin is frequently associated with tumor formation and progression. Besides its role in physic...
In vitro methods have shown that cancer invasion results from the balance of activation and inactiva...
E-cadherin is crucial to the intercellular adherens junctions which are involved in the organisation...
textabstractThe E-cadherin-catenin complex plays a crucial role in epithelial cell-cell adhesion and...
The extraordinary high number of metastases in pancreatic cancer prompted us to analyse the relevanc...
<div><p>P120-catenin (p120ctn) exerts important roles in regulating E-cadherin and invasiveness in c...
The binding of p120-catenin and β-catenin to the cytoplasmic domain of E-cadherin establishes epithe...
The binding of p120-catenin and β-catenin to the cytoplasmic domain of E-cadherin establishes epithe...
P-cadherin overexpression is associated with worse breast cancer survival, being a poor prognostic m...
The epithelial mesenchymal transition (EMT) is an important process in tumor development. Despite pr...
The cadherin/catenin complex plays a key role in the initiation of cell- cell recognition, and adhes...
Adherens junctions consist of transmembrane cadherins, which interact intracellularly with p120ctn, ...
p120-catenin is considered to be a tumor suppressor because it stabilizes E-cadherin levels at the c...
E-cadherin is a cell-cell adhesion protein fulfilling a prominent role in epithelial differentiation...
Down-regulation of the epithelial cell-cell adhesion molecule E-cadherin is frequently associated wi...
E-cadherin is frequently associated with tumor formation and progression. Besides its role in physic...
In vitro methods have shown that cancer invasion results from the balance of activation and inactiva...
E-cadherin is crucial to the intercellular adherens junctions which are involved in the organisation...
textabstractThe E-cadherin-catenin complex plays a crucial role in epithelial cell-cell adhesion and...