The recent discovery of the estrogen receptors alpha and beta (ER, ER) and the progesterone receptor (PR) in human prostate tissue offers new insights into the role of estrogens and their receptors in prostate cancer development and tumor progression. The differentiation compartment of the prostatic epithelium (secretory luminal cells) expresses high levels of ER, while the ER is restricted to the proliferation compartment (basal cells). In high grade prostatic intraepithelial neoplasia (HGPIN), ER gene expression extends to luminal cells and thus may mediate cancerogenic effects of estrogens on the dysplastic epithelium. Conversely, the ER is downregulated in HGPIN indicating that the chemopreventive effects of phytoestrogens mediated by t...
Prostate cancer is the commonest, non-cutaneous cancer in men. At present, there is no cure for the ...
Prostate cancer (PCa) treatment was first established by Huggins and Hodges in 1941, primarily descr...
AbstractIn combination with androgens, estrogens can induce aberrant growth and malignancy of the pr...
The present review gives a survey on the differential expression of estrogen receptors alpha and bet...
Prostate cancer (PC) is characterised by dependence upon androgen receptor (AR) as its driving oncog...
The aim of this study was to identify the expression, cellular localization and regulation of classi...
Although androgen receptor (AR) signaling is the main molecular tool regulating growth and function ...
A major challenge in clinical management of prostate cancer (PC) is to limit tumor growth and preven...
Background: Prostate is the site of two of the most common diseases in elderly men, BPH and Prostati...
The androgen receptor (AR) signaling pathway is one of the key pathways deregulated in prostate canc...
An antibody, GC-17, thoroughly characterized for its specificity for estrogen receptor-beta (ER-beta...
Estrogens were once used for the treatment of prostate cancer (PC). They may still be used in variou...
The role of oestrogens in the development of prostate cancer is poorly understood. However, a large ...
Despite the androgen dependence of the prostate, estrogens are also known to play a role in both the...
Background: Owing to the high incidence rate and the lack of effective treatments, androgen-independ...
Prostate cancer is the commonest, non-cutaneous cancer in men. At present, there is no cure for the ...
Prostate cancer (PCa) treatment was first established by Huggins and Hodges in 1941, primarily descr...
AbstractIn combination with androgens, estrogens can induce aberrant growth and malignancy of the pr...
The present review gives a survey on the differential expression of estrogen receptors alpha and bet...
Prostate cancer (PC) is characterised by dependence upon androgen receptor (AR) as its driving oncog...
The aim of this study was to identify the expression, cellular localization and regulation of classi...
Although androgen receptor (AR) signaling is the main molecular tool regulating growth and function ...
A major challenge in clinical management of prostate cancer (PC) is to limit tumor growth and preven...
Background: Prostate is the site of two of the most common diseases in elderly men, BPH and Prostati...
The androgen receptor (AR) signaling pathway is one of the key pathways deregulated in prostate canc...
An antibody, GC-17, thoroughly characterized for its specificity for estrogen receptor-beta (ER-beta...
Estrogens were once used for the treatment of prostate cancer (PC). They may still be used in variou...
The role of oestrogens in the development of prostate cancer is poorly understood. However, a large ...
Despite the androgen dependence of the prostate, estrogens are also known to play a role in both the...
Background: Owing to the high incidence rate and the lack of effective treatments, androgen-independ...
Prostate cancer is the commonest, non-cutaneous cancer in men. At present, there is no cure for the ...
Prostate cancer (PCa) treatment was first established by Huggins and Hodges in 1941, primarily descr...
AbstractIn combination with androgens, estrogens can induce aberrant growth and malignancy of the pr...