Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical players in innate immunity and maintenance of lung homeostasis. Until recently, assessing the differential functional contributions of tissue-resident versus recruited macrophages has been challenging because they share overlapping cell surface markers, making it difficult to separate them using conventional methods. This review describes how scRNA-seq and spatial transcriptomics can separate these subpopulations and help unravel the complexity of macrophage biology in homeostasis and disease. First, we provide a guide to identifying and distinguishing lung macrophages from other mononuclear phagocytes in humans and mice. Second, we outline emerging...
The lung is continuously exposed to potentially hazardous environmental challenges in the form of in...
Abstract Background Peripheral blood monocytes (PBMo) originate from the bone marrow, circulate in t...
peer reviewedRespiratory infections and especially viral infections, along with other extrinsic envi...
Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical players...
The lung is inhabited by resident alveolar and interstitial macrophages as well as monocytic cells t...
Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis, inflamm...
Macrophages are key immune cells, where they play a pivotal role in host defense and tissue homeosta...
peer reviewedResident tissue macrophages (RTM) can fulfill various tasks during development, homeost...
Abstract Pulmonary macrophages, such as tissue-resident alveolar and interstitial macrophages and re...
peer reviewedMacrophages are a heterogeneous cell population involved in tissue homeostasis, inflamm...
At the early stages of life development, alveoli are colonized by embryonic macrophages, which becom...
Pulmonary fibrosis is an irreversible and progressive disease affecting the lungs, and the etiology ...
For a long time, investigations about the lung myeloid compartment have been mainly limited to the m...
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins by...
Little is known about the relative importance of monocyte and tissue-resident macrophages in the dev...
The lung is continuously exposed to potentially hazardous environmental challenges in the form of in...
Abstract Background Peripheral blood monocytes (PBMo) originate from the bone marrow, circulate in t...
peer reviewedRespiratory infections and especially viral infections, along with other extrinsic envi...
Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical players...
The lung is inhabited by resident alveolar and interstitial macrophages as well as monocytic cells t...
Resident tissue macrophages (RTM) can fulfill various tasks during development, homeostasis, inflamm...
Macrophages are key immune cells, where they play a pivotal role in host defense and tissue homeosta...
peer reviewedResident tissue macrophages (RTM) can fulfill various tasks during development, homeost...
Abstract Pulmonary macrophages, such as tissue-resident alveolar and interstitial macrophages and re...
peer reviewedMacrophages are a heterogeneous cell population involved in tissue homeostasis, inflamm...
At the early stages of life development, alveoli are colonized by embryonic macrophages, which becom...
Pulmonary fibrosis is an irreversible and progressive disease affecting the lungs, and the etiology ...
For a long time, investigations about the lung myeloid compartment have been mainly limited to the m...
Tissue fibrosis is a major cause of mortality that results from the deposition of matrix proteins by...
Little is known about the relative importance of monocyte and tissue-resident macrophages in the dev...
The lung is continuously exposed to potentially hazardous environmental challenges in the form of in...
Abstract Background Peripheral blood monocytes (PBMo) originate from the bone marrow, circulate in t...
peer reviewedRespiratory infections and especially viral infections, along with other extrinsic envi...