Liver X receptors (LXRs) are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. However, exactly how LXRs modulate inflammation during infection remains unknown. To explore this, we used a mouse model of Mycobacterium tuberculosis infection. Upon intratracheal infection with M. tuberculosis, LXRs and LXR target genes were induced in CD11c(+) lung and alveolar cells. Furthermore, mice deficient in both LXR isoforms, LXR alpha and LXR beta (Lxra(-/-)Lxrb(-/-) mice), were more susceptible to infection, developing higher bacterial burdens and an increase in the size and number of granulomatous lesions. Interestingly, mice solely deficient in LXR alpha, but not those lackin...
<div><p>Apoptosis inhibitor of macrophages (AIM), a scavenger protein secreted by tissue macrophages...
<div><p>Acute resistance to low dose <i>M. tuberculosis</i> (Mtb) infection is not dependent on Toll...
AbstractThe liver X receptors (LXRs) are nuclear receptors with established roles in the regulation ...
Liver X receptors (LXRs) are key regulators of macrophage function, controlling transcriptional prog...
Liver X receptors (LXRs) are key regulators of macrophage function, controlling transcriptional prog...
Within this dissertation we have first addressed macrophage (MΦ) and airway responses in mice to the...
Within this dissertation we have first addressed macrophage (MΦ) and airway responses in mice to the...
BACKGROUND:The interaction between Mycobacterium tuberculosis (Mtb) and host cells is complex and fa...
The Liver X receptors (LXRs), Liver X receptor A (LXRA) and Liver X receptor B (LXRB), regulate lipi...
The critical role of cellular immunity during tuberculosis (TB) has been extensively studied, but th...
Tuberculosis is the leading cause of death by an infectious disease worldwide¹. However, the involve...
BackgroundThe liver X receptors (LXRs) are a family of nuclear receptor transcription factors that a...
SummaryMuch of the pronounced host inflammatory response that occurs in tuberculosis (TB) is related...
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (...
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (...
<div><p>Apoptosis inhibitor of macrophages (AIM), a scavenger protein secreted by tissue macrophages...
<div><p>Acute resistance to low dose <i>M. tuberculosis</i> (Mtb) infection is not dependent on Toll...
AbstractThe liver X receptors (LXRs) are nuclear receptors with established roles in the regulation ...
Liver X receptors (LXRs) are key regulators of macrophage function, controlling transcriptional prog...
Liver X receptors (LXRs) are key regulators of macrophage function, controlling transcriptional prog...
Within this dissertation we have first addressed macrophage (MΦ) and airway responses in mice to the...
Within this dissertation we have first addressed macrophage (MΦ) and airway responses in mice to the...
BACKGROUND:The interaction between Mycobacterium tuberculosis (Mtb) and host cells is complex and fa...
The Liver X receptors (LXRs), Liver X receptor A (LXRA) and Liver X receptor B (LXRB), regulate lipi...
The critical role of cellular immunity during tuberculosis (TB) has been extensively studied, but th...
Tuberculosis is the leading cause of death by an infectious disease worldwide¹. However, the involve...
BackgroundThe liver X receptors (LXRs) are a family of nuclear receptor transcription factors that a...
SummaryMuch of the pronounced host inflammatory response that occurs in tuberculosis (TB) is related...
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (...
The role of Toll-like receptors (TLR) and MyD88 for immune responses to Mycobacterium tuberculosis (...
<div><p>Apoptosis inhibitor of macrophages (AIM), a scavenger protein secreted by tissue macrophages...
<div><p>Acute resistance to low dose <i>M. tuberculosis</i> (Mtb) infection is not dependent on Toll...
AbstractThe liver X receptors (LXRs) are nuclear receptors with established roles in the regulation ...