One experimental approach for the treatment of allergic reactions is the stimulation of immunoregulatory NKT cells with the synthetic glycolipid galactosylceramide. For a first evaluation of the immunomodulatory potential of GalCerMPEG a human in vitro allergy model was exploited. Acting as an adjuvant, the glycolipid induced an enhanced Th1-biased allergen-specific immune response of autologous lymphocytes. In a mouse model of allergic airway inflammation, GalCerMPEG-activated NKT cells promoted a cytokine environment in the spleen, leading to priming of Th1 cells. The shift towards a Th1-dominated allergen-specific immune response thus might mediate the abrogation of allergic airway inflammation and thereby might provide a valid option fo...
CID1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory ...
[eng] The Immune System (IS) is a complex collection of tissues, organs, cells and molecules to def...
Alpha-Galactosylceramides are known to activate invariant natural killer (iNK) T cells which are a s...
One experimental approach for the treatment of allergic reactions is the stimulation of immunoregula...
International audienceAllergic asthma is a multifaceted syndrome consisting of eosinophil-rich airwa...
Vα14 natural killer T (NKT) cells produce large amounts of both IL-4 and IFN-γ upon stimulation with...
Invariant NKT iNKT cells bridge innate and adaptive immune responses, resulting in the expansion of ...
Potent vaccine formulations ideally include adjuvants to activate innate immune responses and enhanc...
NKT cells represent a unique subset of immunoregulatory T cells that recognize glycolipid Ags presen...
The prevalence of asthma continues to increase in westernized countries, and optimal treatment remai...
Immunity evolves as a powerful defense system to protect organisms from pathogens. Based on the diff...
In a previous study we demonstrated that intranasal (i.n.) vaccination promotes a Th17 biased immune...
CD1d restricted, alpha-galactosylceramide (alphaGC) responsive invariant (i)NKT cells positively reg...
The glycosphingolipid a-galactosylceramide (alpha-GalCer) has been shown to be a potent activator of...
Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massi...
CID1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory ...
[eng] The Immune System (IS) is a complex collection of tissues, organs, cells and molecules to def...
Alpha-Galactosylceramides are known to activate invariant natural killer (iNK) T cells which are a s...
One experimental approach for the treatment of allergic reactions is the stimulation of immunoregula...
International audienceAllergic asthma is a multifaceted syndrome consisting of eosinophil-rich airwa...
Vα14 natural killer T (NKT) cells produce large amounts of both IL-4 and IFN-γ upon stimulation with...
Invariant NKT iNKT cells bridge innate and adaptive immune responses, resulting in the expansion of ...
Potent vaccine formulations ideally include adjuvants to activate innate immune responses and enhanc...
NKT cells represent a unique subset of immunoregulatory T cells that recognize glycolipid Ags presen...
The prevalence of asthma continues to increase in westernized countries, and optimal treatment remai...
Immunity evolves as a powerful defense system to protect organisms from pathogens. Based on the diff...
In a previous study we demonstrated that intranasal (i.n.) vaccination promotes a Th17 biased immune...
CD1d restricted, alpha-galactosylceramide (alphaGC) responsive invariant (i)NKT cells positively reg...
The glycosphingolipid a-galactosylceramide (alpha-GalCer) has been shown to be a potent activator of...
Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massi...
CID1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory ...
[eng] The Immune System (IS) is a complex collection of tissues, organs, cells and molecules to def...
Alpha-Galactosylceramides are known to activate invariant natural killer (iNK) T cells which are a s...