In this work, we present a novel laboratory-based micro-computed tomography (micro-CT) experiment designed to investigate the pore scale drainage behavior of natural sandstone under dynamic conditions. The fluid distribution in a Bentheimer sandstone was visualized every 4 seconds with a 12 second measurement time, allowing the investigation of single- and few-pore filling events. To our knowledge, this is the first time that such measurements were performed outside of synchrotron facilities, illustrating the growing application potential of lab-based micro-CT with sub-minute temporal resolutions for geological research at the pore scale. To illustrate how the workflow can lead to an improved understanding of drainage behavior, the experime...