Assessment of the antineoplastic potential of chalcones in animal models

One part of chem. space that is endowed with interesting biol. properties is the area of the chalcones. With this review, we provide a comprehensive overview of the numerous in vivo animal studies on the antineoplastic potential of both natural and synthetic members of this flavonoid subclass (covering: up to mid-2011). The thus far identified modes of action of these compds. are also discussed. We hope that this overview may stimulate deeper investigations into the biochem. mechanisms by which chalcones exert their antineoplastic action. As a result, in the foreseeable future, chalcones may prove suitable lead mols. or early drug candidates for the prevention or treatment of various neoplastic diseases.One part of chem. space that is endowed with interesting biol. properties is the area of the chalcones. With this review, we provide a comprehensive overview of the numerous in vivo animal studies on the antineoplastic potential of both natural and synthetic members of this flavonoid subclass (covering: up to mid-2011). The thus far identified modes of action of these compds. are also discussed. We hope that this overview may stimulate deeper investigations into the biochem. mechanisms by which chalcones exert their antineoplastic action. As a result, in the foreseeable future, chalcones may prove suitable lead mols. or early drug candidates for the prevention or treatment of various neoplastic diseases.A