Context. The far-infrared (FIR) lines are important tracers of the cooling and physical conditions of the interstellar medium (ISM) and are rapidly becoming workhorse diagnostics for galaxies throughout the universe. There are clear indications of a different behavior of these lines at low metallicity that needs to be explored. Aims. Our goal is to explain the main differences and trends observed in the FIR line emission of dwarf galaxies compared to more metal-rich galaxies, and how this translates in ISM properties. Methods. We present Herschel/PACS spectroscopic observations of the [C II] 157 mu m, [O I] 63 and 145 mu m, [O III] 88 mu m, [N II] 122 and 205 mu m, and [N III] 57 mu m fine-structure cooling lines in a sample of 48 low-metal...