Epidermal keratinocytes provide an essential structural and immunological barrier forming the first line of defense against potentially pathogenic microorganisms. Mechanisms regulating barrier integrity and innate immune responses in the epidermis are important for the maintenance of skin immune homeostasis and the pathogenesis of inflammatory skin diseases. Here, we show that epidermal keratinocyte-restricted deficiency of the adaptor protein FADD (FADD(E-KO)) induced severe inflammatory skin lesions in mice. The development of skin inflammation in FADD(E-KO) mice was triggered by RIP kinase 3 (RIP3)-mediated programmed necrosis (termed necroptosis) of FADD-deficient keratinocytes, which was partly dependent on the deubiquitinating enzyme ...
Recent findings have implicated Fas/Fas ligand (FasL) in mediating the death of keratinocytes in spo...
The epidermis is part of the innate immune system and represents the first line of defense against e...
SummaryInflammatory diseases at epithelial borders develop from aberrant interactions between reside...
Epidermal keratinocytes provide an essential structural and immunological barrier forming the first ...
Epidermal keratinocytes provide an essential structural and immunological barrier forming the first ...
SummaryEpidermal keratinocytes provide an essential structural and immunological barrier forming the...
In this issue of Immunity, Bonnet et al. (2011) show that skin-specific ablation of the adaptor prot...
Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, ...
SummaryFADD, caspase-8, and cFLIP regulate the outcome of cell death signaling. Mice that constituti...
FADD, caspase-8, and cFLIP regulate the outcome of cell death signaling. Mice that constitutively la...
The presence of dying cells in inflamed tissues has been recognized since many years, but until rece...
Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, t...
Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiqui...
Recent findings have implicated Fas/Fas ligand (FasL) in mediating the death of keratinocytes in spo...
Tumor necrosis factor receptor 1 (TNFR1) activates NF-kappa B-dependent pro- inflammatory gene expre...
Recent findings have implicated Fas/Fas ligand (FasL) in mediating the death of keratinocytes in spo...
The epidermis is part of the innate immune system and represents the first line of defense against e...
SummaryInflammatory diseases at epithelial borders develop from aberrant interactions between reside...
Epidermal keratinocytes provide an essential structural and immunological barrier forming the first ...
Epidermal keratinocytes provide an essential structural and immunological barrier forming the first ...
SummaryEpidermal keratinocytes provide an essential structural and immunological barrier forming the...
In this issue of Immunity, Bonnet et al. (2011) show that skin-specific ablation of the adaptor prot...
Intestinal immune homeostasis depends on a tightly regulated cross talk between commensal bacteria, ...
SummaryFADD, caspase-8, and cFLIP regulate the outcome of cell death signaling. Mice that constituti...
FADD, caspase-8, and cFLIP regulate the outcome of cell death signaling. Mice that constitutively la...
The presence of dying cells in inflamed tissues has been recognized since many years, but until rece...
Necroptosis has emerged as an important pathway of programmed cell death in embryonic development, t...
Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiqui...
Recent findings have implicated Fas/Fas ligand (FasL) in mediating the death of keratinocytes in spo...
Tumor necrosis factor receptor 1 (TNFR1) activates NF-kappa B-dependent pro- inflammatory gene expre...
Recent findings have implicated Fas/Fas ligand (FasL) in mediating the death of keratinocytes in spo...
The epidermis is part of the innate immune system and represents the first line of defense against e...
SummaryInflammatory diseases at epithelial borders develop from aberrant interactions between reside...