Optical spectroscopy and obstacles by non-invasive detection of glucose concentration by home monitoring

Tight glycemic monitoring and control is the main goal in successful diabetes management to avoid its complications. Frequent blood glucose measurements with a combination of regimented diet, exercise and insulin administration can accomplish this task. Different methods are applied for non-invasive measurement of blood glucose concentration. Despite the great interest and the intensive research in this field since 1980s, there is no convenient device at the market that can measure the glucose concentration non-invasively in an easy manner. This paper discusses the different methods for detecting the glucose concentration. Elastic and inelastic (Raman) scattering as well as fluorescence and IR Spectroscopy measurements well be shown and discussed for the development of a compact non-invasive device for home monitoring. In conclusions, an optical multi-sensor measuring the fluorescence and light scattering in the tissue optical window in and around visible range (360 nm - 1200 nm) taking the perturbation factors into account is promising and under development