Perspective Chapter: VNS Nerve Stimulation in Epilepsy through Lifespan

Vagus nerve stimulation (VNS) has emerged as a significant therapeutic intervention for individuals with drug-resistant epilepsy (DRE) throughout their lifespan. DRE is a debilitating condition characterized by recurrent seizures that do not respond to traditional antiepileptic drugs, imposing substantial physical, cognitive, and emotional burdens on patients. VNS involves the implantation of a device that delivers electrical impulses to the vagus nerve, a major nerve connecting the brain to various organs. The mechanism of action is complex and not yet fully understood, but VNS has been found to modulate abnormal electrical activity in the brain, reducing the frequency and severity of seizures. This non-pharmacological approach offers a valuable alternative for patients who have exhausted conventional treatment options, improves their quality of life, and provides hope for seizure control. Importantly, VNS has demonstrated efficacy across different age groups, from children to adults, making it suitable for lifelong management of DRE. Furthermore, long-term studies have shown sustained benefits and safety of VNS, with potential positive effects on cognitive function and mood regulation. As a result, VNS represents a promising adjunctive therapy that can significantly impact the lives of individuals with drug-resistant epilepsy, offering them renewed hope and the potential for a better future