Antiphospholipid syndrome (APS) is defined by thrombosis, fetal loss, and the presence of antiphospholipid antibodies, including anti-beta 2-glycoprotein-1 autoantibodies (anti-beta 2GP1) that have a direct role in the pathogenesis of thrombosis in vivo. The cellular targets of the anti-beta 2GP1autoantibody/beta 2GP1complex in vivo were studied using a laser-induced thrombosis model of APS in a live mouse and human anti-beta 2GP1 autoantibodies affinity-purified from APS patients. Cell binding of fluorescently labeled beta 2GP1 and anti-beta 2GP1 autoantibodies revealed their colocalization on the platelet thrombus but not the endothelium. Anti-beta 2GP1 autoantibodies enhanced platelet activation, monitored by calcium mobilization, and en...
The thrombogenic effect of \u3b22-glycoprotein I (\u3b22GPI)-dependent anti-phospholipid antibodies ...
Objective. IgG aPL against domain I of β2-glycoprotein I (β2GPI) [anti-DI (aDI)] is associated with ...
Antiphospholipid syndrome (APS) is characterized by the presence of recurrent venous/ arterial thro...
Antiphospholipid syndrome (APS) is defined by thrombosis, fetal loss, and the presence of antiphosph...
Antiphospholipid syndrome (APS) is an autoimmune-mediated acquired thrombophilia characterized by ve...
Antiphospholipid syndrome (APS) is characterized by recurrent thrombosis or pregnancy morbidity asso...
Anti-phospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy...
Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibodies cause clinical eff...
Antiphospholipid syndrome (APS) is characterized by the presence of recurrent venous/ arterial throm...
The associationof antiphospholipid(aPL) antibodieswith thrombosisin patientswith antiphospholipid sy...
The antiphospholipid syndrome (APS) is a non-inflammatory autoimmune disease clinically characterize...
Antiphospholipid syndrome (APS) is characterized by recurrent arterial/venous thrombosis and miscarr...
Antiphospholipid syndrome (APS) is an antibody-mediated hypercoagulable state characterized by recur...
Anti-beta-2 glycoprotein 1 (β2GP1) antibodies, β2GP1 and platelets are key elements responsible for ...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115902/1/art39247.pd
The thrombogenic effect of \u3b22-glycoprotein I (\u3b22GPI)-dependent anti-phospholipid antibodies ...
Objective. IgG aPL against domain I of β2-glycoprotein I (β2GPI) [anti-DI (aDI)] is associated with ...
Antiphospholipid syndrome (APS) is characterized by the presence of recurrent venous/ arterial thro...
Antiphospholipid syndrome (APS) is defined by thrombosis, fetal loss, and the presence of antiphosph...
Antiphospholipid syndrome (APS) is an autoimmune-mediated acquired thrombophilia characterized by ve...
Antiphospholipid syndrome (APS) is characterized by recurrent thrombosis or pregnancy morbidity asso...
Anti-phospholipid syndrome (APS) is characterized by arterial and/or venous thrombosis and pregnancy...
Antiphospholipid syndrome (APS) is an autoimmune disorder in which autoantibodies cause clinical eff...
Antiphospholipid syndrome (APS) is characterized by the presence of recurrent venous/ arterial throm...
The associationof antiphospholipid(aPL) antibodieswith thrombosisin patientswith antiphospholipid sy...
The antiphospholipid syndrome (APS) is a non-inflammatory autoimmune disease clinically characterize...
Antiphospholipid syndrome (APS) is characterized by recurrent arterial/venous thrombosis and miscarr...
Antiphospholipid syndrome (APS) is an antibody-mediated hypercoagulable state characterized by recur...
Anti-beta-2 glycoprotein 1 (β2GP1) antibodies, β2GP1 and platelets are key elements responsible for ...
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/115902/1/art39247.pd
The thrombogenic effect of \u3b22-glycoprotein I (\u3b22GPI)-dependent anti-phospholipid antibodies ...
Objective. IgG aPL against domain I of β2-glycoprotein I (β2GPI) [anti-DI (aDI)] is associated with ...
Antiphospholipid syndrome (APS) is characterized by the presence of recurrent venous/ arterial thro...