Biofilm inhibitory potential of Oscillatoria tenuis against Candida albicans

Prokaryotic autotrophs have a key role in maintaining the sustainability of nature. Their secondary metabolites and stored chemicals have wide utility in human life. Cyanophytes, the primitive producers, can become a necessity of the modern world as they have enormous unexplored features. Candida albicans, an opportunistic pathogen having multidrug resistance, fallout health concerns in human and animal hosts. This study focused on the antibiofilm potential of Oscillatoria tenuis NTAPD 02, isolated from a hydrocarbon-polluted area against the hyphal switching of Candida albicans. Ethanolic extract of the algal sample, OEE, was taken to perform the biofilm quantification test and CLSM studies to determine the antibiofilm potential of Oscillatoria tenuis against Candida albicans. The MBIC for OEE was found to be 30 µg/mL against C. albicans and also shows a 70.8% reduction of fungal biofilm. The GC-MS and FTIR analysis illustrates the presence of potent phenolic hydrocarbons having an anti-proliferative effect. OEE was also found stress generative in C. elegans (500 µg/mL). The ROS generation in the worms intensified by increased concentration of OEE. The study proves that Oscillatoria tenuis, NTAPD 02, can be considered an anti-proliferative alga against C. albicans invasions