Bilateral asymmetry in microarchitecture of trabecular bone in male c57bl/6 mouse tibia: Implication for experimental sample size estimations

Ko, C.-Y.
Jung, Y.-J.
Seo, D.H.
Kim, H.S.

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Publication date

January 2013

DOI

10.1177/0954411913485053

ISSN

0954-4119

Citation count (estimate)

Abstract

This study aimed to determine whether there is bilateral asymmetry between the left and right tibiae in the microarchitectural characteristics of the trabecular bone and estimate a moderate sample size for detections of such bilateral differences. The left and right tibiae of 20 C57BL/6 mice (12 weeks old) were scanned by micro-computed tomography, and the structural parameters of the trabecular bone were measured. There were significant differences in the structural parameters between the left and right tibiae (p<0.05); specifically, the microarchitecture was greater in quantity and quality in the left tibia than in the right tibia. Moreover, the percent of bilateral differences between the left and right tibiae ranged from 2.26% to 22.52%...