Severe asthma and viral-induced asthma exacerbations represent a high unmet medical need as no therapy is currently available for these patients. HRV (human rhinovirus) is prominently associated with asthma exacerbations in humans. The aim of the present study was to establish a mouse model of severe asthma with additional rhinovirus infection to investigate the interplay between chronic allergic airway inflammation and acute respiratory viral infection. Balb/c mice were sensitized with HDM (house dust mite) extract (25 µg in 50 µl of saline) by i.n. (intranasal) delivery to the lung over 7 weeks. HRV1B (HRV serotype 1B) inoculation was performed i.n. on the last 3 days. Therapeutic treatment with FP (fluticasone propionate) was performed t...
Respiratory viruses, including rhinovirus (RV), are responsible for 80% of asthma exacerbations in c...
Mast cells (MCs) are classically involved in the pathogenesis of allergic asthma, however MCs also h...
BACKGROUND: Acute worsening of asthma symptoms (exacerbation) is predominantly triggered by respirat...
Most asthma exacerbations are triggered by virus infections, the majority being caused by human rhin...
Most asthma exacerbations are triggered by virus infections, the majority being caused by human rhin...
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigat...
PurposeThe aim of the present study was to investigate the differences in lower airway inflammatory ...
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigat...
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigat...
<div><p>Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies in...
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigat...
Several epidemiological studies using sensitive detection methodologies have confirmed that the majo...
Several epidemiological studies using sensitive detection methodologies have confirmed that the majo...
Respiratory viruses, including rhinovirus (RV), are responsible for 80% of asthma exacerbations in c...
Viral respiratory infection exacerbates asthma symptoms in almost all patients with allergic asthma...
Respiratory viruses, including rhinovirus (RV), are responsible for 80% of asthma exacerbations in c...
Mast cells (MCs) are classically involved in the pathogenesis of allergic asthma, however MCs also h...
BACKGROUND: Acute worsening of asthma symptoms (exacerbation) is predominantly triggered by respirat...
Most asthma exacerbations are triggered by virus infections, the majority being caused by human rhin...
Most asthma exacerbations are triggered by virus infections, the majority being caused by human rhin...
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigat...
PurposeThe aim of the present study was to investigate the differences in lower airway inflammatory ...
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigat...
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigat...
<div><p>Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies in...
Human rhinovirus is a key viral trigger for asthma exacerbations. To date, murine studies investigat...
Several epidemiological studies using sensitive detection methodologies have confirmed that the majo...
Several epidemiological studies using sensitive detection methodologies have confirmed that the majo...
Respiratory viruses, including rhinovirus (RV), are responsible for 80% of asthma exacerbations in c...
Viral respiratory infection exacerbates asthma symptoms in almost all patients with allergic asthma...
Respiratory viruses, including rhinovirus (RV), are responsible for 80% of asthma exacerbations in c...
Mast cells (MCs) are classically involved in the pathogenesis of allergic asthma, however MCs also h...
BACKGROUND: Acute worsening of asthma symptoms (exacerbation) is predominantly triggered by respirat...