Baseline Characteristics and Outcomes of Cancer Patients Infected with SARS-CoV-2 in the Lombardy Region, Italy (AIOM-L CORONA): A Multicenter, Observational, Ambispective, Cohort Study

Simple SummaryCancer patients show an increased vulnerability to SARS-CoV-2 infection and may experience severe COVID-19 complications. AIOM-L Corona aimed to assess the prognostic factors associated with outcomes in 231 cancer patients infected by SARS-CoV-2 between March and September 2020 in Lombardy, the most extensively affected Italian region. A total of 93 events occurred. Known risk factors for mortality in COVID-19 remained significant in the study population. Specifically, age >= 60 years, metastases, dyspnea, desaturation, and interstitial pneumonia were all associated with mortality. Notably, metastatic patients receiving systemic active therapy were less likely to die as compared to untreated counterparts, even after adjusting for other confounding variables (Odds Ratio 0.23, 95%CI 0.11-0.51, p = 60 years, metastatic dissemination, dyspnea, desaturation, and interstitial pneumonia were all independent mortality predictors. Overall SACT had a neutral effect (Odds Ratio [OR] 0.83, 95%Confidence Interval [95%CI] 0.32-2.15); however, metastatic patients receiving SACT were less likely to die as compared to untreated counterparts, after adjusting for other confounding variables (OR 0.23, 95%CI 0.11-0.51, p < 0.001). Among cancer patients infected by SARS-CoV-2, those with metastases were most at risk of death, especially in the absence of SACT. During the ongoing pandemic, these vulnerable patients should avoid exposure to SARS-CoV-2, while treatment adjustments and prioritizing vaccination are being considered according to international recommendations