While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinct control mechanisms enable HSC divisions that generate progeny cells with specific lineage bias. Here, we report that the monocytic transcription factor MafB specifically restricts the ability of M-CSF to instruct myeloid commitment divisions in HSCs. MafB deficiency specifically enhanced sensitivity to M-CSF and caused activation of the myeloid master-regulator PU.1 in HSCs in vivo. Single-cell analysis revealed that reduced MafB levels enabled M-CSF to instruct divisions producing asymmetric daughter pairs with one PU.1+ cell. As a consequence, MafB−/− HSCs showed a PU.1 and M-CSF receptor-dependent competitive repopulation advantage speci...
SummaryThe transcriptional circuitry that regulates the quiescence of hematopoietic stem cells is la...
Macrophages and myeloid dendritic cells (DCs) represent alternative differentiation options of bone ...
The activity of adult stem cells is essential to replenish mature cells constantly lost due to norma...
International audienceWhile hematopoietic stem cell (HSC) self-renewal is well studied, it remains u...
While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinc...
SummaryWhile hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether ...
Upregulation of specific transcription factors is a generally accepted mechanism to explain the comm...
In metazoan organisms, terminal differentiation is generally tightly linked to cell cycle exit, wher...
International audienceIn metazoan organisms, terminal differentiation is generally tightly linked to...
Under stress conditions such as infection or inflammation the body rapidly needs to generate new blo...
International audienceDifferentiated macrophages can self-renew in tissues and expand long term in c...
SummaryConsensus holds that hematopoietic stem cells (HSCs) give rise to multipotent progenitors (MP...
During the execution of differentiation programs, lineage-specific transcription factors are in comp...
Hematopoietic stem cells (HSCs) are defined by their unique properties to self-renew and differentia...
In adult mammals, Hematopoietic stem cells (HSCs) depend on specialized bone marrow (BM) HSC niches ...
SummaryThe transcriptional circuitry that regulates the quiescence of hematopoietic stem cells is la...
Macrophages and myeloid dendritic cells (DCs) represent alternative differentiation options of bone ...
The activity of adult stem cells is essential to replenish mature cells constantly lost due to norma...
International audienceWhile hematopoietic stem cell (HSC) self-renewal is well studied, it remains u...
While hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether distinc...
SummaryWhile hematopoietic stem cell (HSC) self-renewal is well studied, it remains unknown whether ...
Upregulation of specific transcription factors is a generally accepted mechanism to explain the comm...
In metazoan organisms, terminal differentiation is generally tightly linked to cell cycle exit, wher...
International audienceIn metazoan organisms, terminal differentiation is generally tightly linked to...
Under stress conditions such as infection or inflammation the body rapidly needs to generate new blo...
International audienceDifferentiated macrophages can self-renew in tissues and expand long term in c...
SummaryConsensus holds that hematopoietic stem cells (HSCs) give rise to multipotent progenitors (MP...
During the execution of differentiation programs, lineage-specific transcription factors are in comp...
Hematopoietic stem cells (HSCs) are defined by their unique properties to self-renew and differentia...
In adult mammals, Hematopoietic stem cells (HSCs) depend on specialized bone marrow (BM) HSC niches ...
SummaryThe transcriptional circuitry that regulates the quiescence of hematopoietic stem cells is la...
Macrophages and myeloid dendritic cells (DCs) represent alternative differentiation options of bone ...
The activity of adult stem cells is essential to replenish mature cells constantly lost due to norma...