PURPOSE: Arteriovenous (AV) graft thrombosis is a frequent complication in patients undergoing hemodialysis. Thrombolytic therapy with tissue plasminogen activator (TPA) is hampered by the risk of bleeding complications. Locally delivered plasmin may have similar thrombolytic efficacy with a superior safety profile, so herein it was compared with TPA in a porcine model of AV graft thrombosis. MATERIALS AND METHODS: AV grafts were created bilaterally between the carotid artery and jugular vein. Graft thrombosis was induced by clamping the grafts for 1 hour. On day 3, one graft was treated with a 2-mL local recombinant plasmin injection (10 mg; n = 10) with the contralateral graft being infused with TPA (10 mg, n = 8) or saline solution (n = ...
Background: Patients with acute peripheral arterial occlusion (aPAO) are candidates for operative th...
ObjectivesRecombinant thrombin (rThrombin) is a potential hemostatic alternative to bovine and human...
Copyright 2002 American Heart Association, Inc.Background and Purpose-We sought to test the hypothes...
AbstractPurpose: The advancement of catheter-based interventions for vascular recanalization has und...
Hemodialysis arteriovenous synthetic grafts (AVG) provide high volumetric blood flow rates shortly a...
<div><p>Background</p><p>Hemodialysis arteriovenous synthetic grafts (AVG) provide high volumetric b...
Purpose:Tissue factor pathway inhibitor (TFPI), an endogenous protease, is a potent inhibitor of the...
PURPOSE: Regional thrombolysis in the recanalization of peripheral vascular occlusive disease is an ...
Objectives.This study examined the modification of recombinant tissue-type plasminogen activator (rt...
Background: Thrombolytics such as tissue plasminogen activator are often used by interventional radi...
Tissue plasminogen activator (t-PA) is currently the gold standard of thrombolytic therapy for treat...
Human tissue plasminogen activator holds promise for the dissolution of coronary thrombi by intraven...
The authors employed a canine model of coronary thrombosis, induced by injection of radioactive bloo...
AbstractObjective: The purposes of this study were to evaluate the safety and efficacy of limited-do...
Background Hemodialysis arteriovenous synthetic grafts (AVG) provide high volumetric blood flow rate...
Background: Patients with acute peripheral arterial occlusion (aPAO) are candidates for operative th...
ObjectivesRecombinant thrombin (rThrombin) is a potential hemostatic alternative to bovine and human...
Copyright 2002 American Heart Association, Inc.Background and Purpose-We sought to test the hypothes...
AbstractPurpose: The advancement of catheter-based interventions for vascular recanalization has und...
Hemodialysis arteriovenous synthetic grafts (AVG) provide high volumetric blood flow rates shortly a...
<div><p>Background</p><p>Hemodialysis arteriovenous synthetic grafts (AVG) provide high volumetric b...
Purpose:Tissue factor pathway inhibitor (TFPI), an endogenous protease, is a potent inhibitor of the...
PURPOSE: Regional thrombolysis in the recanalization of peripheral vascular occlusive disease is an ...
Objectives.This study examined the modification of recombinant tissue-type plasminogen activator (rt...
Background: Thrombolytics such as tissue plasminogen activator are often used by interventional radi...
Tissue plasminogen activator (t-PA) is currently the gold standard of thrombolytic therapy for treat...
Human tissue plasminogen activator holds promise for the dissolution of coronary thrombi by intraven...
The authors employed a canine model of coronary thrombosis, induced by injection of radioactive bloo...
AbstractObjective: The purposes of this study were to evaluate the safety and efficacy of limited-do...
Background Hemodialysis arteriovenous synthetic grafts (AVG) provide high volumetric blood flow rate...
Background: Patients with acute peripheral arterial occlusion (aPAO) are candidates for operative th...
ObjectivesRecombinant thrombin (rThrombin) is a potential hemostatic alternative to bovine and human...
Copyright 2002 American Heart Association, Inc.Background and Purpose-We sought to test the hypothes...