GIGYF2 mutations are not a frequent cause of familial Parkinson's disease
- Di Fonzo, Alessio
- Fabrizio, E
- Thomas, A
- Fincati, E
- Marconi, R
- Tinazzi, M
- Breedveld, Guido
- Simons, Erik
- Chien, HF
- Ferreira, JJ
- Horstink, W
- Abbruzzese, G
- Borroni, B
- Cossu, G
- Dalla Libera, A
- Fabbrini, G
- Guidi, M
- de Mari, M
- Lopiano, L
- Martignoni, E
- Marini, P
- Onofrj, M
- Padovani, A
- Stocchi, F
- Toni, V
- Sampaio, C
- Barbosa, ER
- Meco, G
- Oostra, Ben
- Bonifati, Vincenzo
Publication date
January 2009
DOIAbstract
Mutations in the Grb10-interacting GYF protein 2 (GIGYF2) gene, within the PARK11 locus, have been nominated as a cause of Parkinson's disease in Italian and French populations. By sequencing the whole GIGYF2 coding region in forty-six probands (thirty-seven Italians) with familial Parkinson's disease compatible with an autosomal dominant inheritance, we identified no mutations. Our data add to a growing body of evidence suggesting that GIGYF2 mutations are not a frequent cause of PD. (C) 2009 Elsevier Ltd. All rights reserved
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