Endothelial protein C activation in meningococcal sepsis

To the Editor: In the August 9 issue, Faust et al. reported that the level of endothelial expression of thrombomodulin and the endothelial protein C receptor was lower in patients with meningococcal sepsis than in control subjects. This finding has clinical implications, because it suggests that therapy with activated protein C2 may be superior to treatment with unactivated protein C3 in patients with sepsis. [...