[1] We explore the idea that the relative size distribution of earthquakes, quantified using the so-called b-value, is negatively correlated with differential stress. Because the maximum possible differential stress increases linearly in the brittle upper crust, we expect to find a decrease of b with depth. We test this expectation for seven continental areas around the world, each of which is described by a regional earthquake catalog. We find a monotonic decrease in b-value between 5 and 15 km depth. The decrease stops near the brittle-ductile transition. We specifically focus on the high-quality catalogs of earthquakes in California to perform a sensitivity test with respect to depth uncertainty; we also estimate the probability-depth gr...