Applications of control engineering to mammalian cell biology have been recently implemented for precise regulation of gene expression. In this chapter, we report the main experimental and computational methodologies to implement automatic feedback control of gene expression in mammalian cells using a microfluidics/microscopy platform
Mammalian cells are dynamical systems. They detect, adapt and respond to time-varying inputs such as...
<div><p>We describe an innovative experimental and computational approach to control the expression ...
Real-time automatic regulation of gene expression is a key technology for synthetic biology enabling...
Abstract Gene networks and signaling pathways display complex topologies and, as a result, complex ...
Gene networks and signaling pathways display complex topologies and, as a result, complex nonlinear ...
International audienceBy implementing an external feedback loop one can tightly control the expressi...
Automatic control of gene expression in living cells is paramount importance to characterize both en...
Automatic control of gene expression in living cells is paramount importance to characterize both en...
We describe an innovative experimental and computational approach to control the expression of a pro...
We describe an innovative experimental and computational approach to control the expression of a pro...
Observation of single-cell behavior has become increasingly important to our understanding of comple...
Mammalian cells are dynamical systems. They detect, adapt and respond to time-varying inputs such as...
<div><p>We describe an innovative experimental and computational approach to control the expression ...
Real-time automatic regulation of gene expression is a key technology for synthetic biology enabling...
Abstract Gene networks and signaling pathways display complex topologies and, as a result, complex ...
Gene networks and signaling pathways display complex topologies and, as a result, complex nonlinear ...
International audienceBy implementing an external feedback loop one can tightly control the expressi...
Automatic control of gene expression in living cells is paramount importance to characterize both en...
Automatic control of gene expression in living cells is paramount importance to characterize both en...
We describe an innovative experimental and computational approach to control the expression of a pro...
We describe an innovative experimental and computational approach to control the expression of a pro...
Observation of single-cell behavior has become increasingly important to our understanding of comple...
Mammalian cells are dynamical systems. They detect, adapt and respond to time-varying inputs such as...
<div><p>We describe an innovative experimental and computational approach to control the expression ...
Real-time automatic regulation of gene expression is a key technology for synthetic biology enabling...