Propionic acid promotes the virulent phenotype of Crohn's Disease-associated adherent-invasive <i>Escherichia coli</i>
- Ormsby, Michael J.
- Johnson, Síle A.
- Carpena, Nuria
- Meikle, Lynsey M.
- Goldstone, Robert J.
- McIntosh, Anne
- Wessel, Hannah M.
- Hulme, Heather E.
- McConnachie, Ceilidh C.
- Connolly, James P. R.
- Roe, Andrew J.
- Hasson, Conor
- Boyd, Joseph
- Fitzgerald, Eamonn
- Gerasimidis, Konstantinos
- Morrison, Douglas
- Hold, Georgina L.
- Hansen, Richard
- Walker, Daniel
- Smith, David G. E.
- Wall, Daniel M.
DOIAbstract
The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).</p
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