Artículo de publicación ISIFolic acid (FA) consumption at high levels has been associated with colon cancer risk. Several mechanisms have been proposed to explain this association. The Notch signal pathway has been implicated in the regulation of cellular proliferation. Our aim was to demonstrate that high concentrations of FA or its reduced form, 5-methyltetrahydrofolic acid (5-MTHF), increase colorectal carcinoma HT29 cell proliferation through an increase of Notch1 activation and to prove if the inhibition of Notch1 activation by gamma secretase inhibitor, reduce the effect of folic acid. HT29 cells were cultured in high (400nM), low (20nM), or 0nM FA or 5-MTHF concentrations during 96h with or without DAPT (gamma secretase inhibitor). C...
Folate and methionine are critical for one-carbon metabolism, impacting DNA synthesis, repair, and m...
Cancer cell lines in standard cell culture medium or in animal models are surrounded by an environme...
Colorectal cancer is one of the most common cancers worldwide and specific nutients have been associ...
Artículo de publicación ISIFolic acid (FA) consumption at high levels has been associated with colon...
Folate, a water-soluble B vitamin, is a cofactor in one-carbon metabolism and is essential for DNA s...
Folate plays a role in the synthesis and repair of DNA and the generation of methyl groups. Folic ac...
Item does not contain fulltextFolate, a water-soluble B vitamin, is a cofactor in one-carbon metabol...
Folic acid (FA) is a synthetic form of vitamin B9, generally used as a nutritional supplement and an...
High folate status from high folic acid (FA) intakes may have unintended and serious deleterious eff...
Roger Bayston and colleagues1 state that, to the best of our knowledge, folic acid does not reduce c...
Folate blood levels in North America have dramatically increased over the past decade owing to folic...
Folate is an essential cofactor in one-carbon transfer reactions including nucleotide biosynthesis, ...
Folic acid, a water-soluble B vitamin contained in vegetables, is essential for maintaining DNA stab...
A growing body of evidence has linked high folic acid (FA) intake to adverse health outcomes, includ...
2018-06-21Background: CRC ranks as the third leading cause of cancer-related death in the industrial...
Folate and methionine are critical for one-carbon metabolism, impacting DNA synthesis, repair, and m...
Cancer cell lines in standard cell culture medium or in animal models are surrounded by an environme...
Colorectal cancer is one of the most common cancers worldwide and specific nutients have been associ...
Artículo de publicación ISIFolic acid (FA) consumption at high levels has been associated with colon...
Folate, a water-soluble B vitamin, is a cofactor in one-carbon metabolism and is essential for DNA s...
Folate plays a role in the synthesis and repair of DNA and the generation of methyl groups. Folic ac...
Item does not contain fulltextFolate, a water-soluble B vitamin, is a cofactor in one-carbon metabol...
Folic acid (FA) is a synthetic form of vitamin B9, generally used as a nutritional supplement and an...
High folate status from high folic acid (FA) intakes may have unintended and serious deleterious eff...
Roger Bayston and colleagues1 state that, to the best of our knowledge, folic acid does not reduce c...
Folate blood levels in North America have dramatically increased over the past decade owing to folic...
Folate is an essential cofactor in one-carbon transfer reactions including nucleotide biosynthesis, ...
Folic acid, a water-soluble B vitamin contained in vegetables, is essential for maintaining DNA stab...
A growing body of evidence has linked high folic acid (FA) intake to adverse health outcomes, includ...
2018-06-21Background: CRC ranks as the third leading cause of cancer-related death in the industrial...
Folate and methionine are critical for one-carbon metabolism, impacting DNA synthesis, repair, and m...
Cancer cell lines in standard cell culture medium or in animal models are surrounded by an environme...
Colorectal cancer is one of the most common cancers worldwide and specific nutients have been associ...