Location matters: the endoplasmic reticulum and protein trafficking in dendrites

Artículo de publicación ISINeurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles a re still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.FONDECYT 3110157 1090246 1100137 ICM P07-048-