Add to ORKGIt is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism...
Purpose of reviewWe focus on the molecular and cellular basis of the improvement in myocardial energ...
Objectives. We will review current concepts regarding bioenergetic decline in heart failure (HF). In...
Heart failure (HF) currently affects more than 37 million people globally and is rising in prevalenc...
It is unknown why heart failure progresses even when patients are treated with the best therapy avai...
It is unknown why heart failure progresses even when patients are treated with the best therapy avai...
Although neurohumoral antagonism has successfully reduced heart failure morbidity and mortality, the...
Despite advances in treatment, chronic heart failure is still associated with significant morbidity ...
The failing heart has an increased metabolic demand and at the same time suffers from impaired energ...
The incidence and prevalence of heart failure have increased significantly over the past few decades...
The morbidity and mortality of coronary heart disease and of heart failure remain unacceptably high ...
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality ...
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality ...
Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal c...
AbstractThe heart is responsible for pumping blood throughout the blood vessels to the periphery by ...
Energy substrate metabolism and contractile function are tightly coupled in the heart. Within this f...
Purpose of reviewWe focus on the molecular and cellular basis of the improvement in myocardial energ...
Objectives. We will review current concepts regarding bioenergetic decline in heart failure (HF). In...
Heart failure (HF) currently affects more than 37 million people globally and is rising in prevalenc...
It is unknown why heart failure progresses even when patients are treated with the best therapy avai...
It is unknown why heart failure progresses even when patients are treated with the best therapy avai...
Although neurohumoral antagonism has successfully reduced heart failure morbidity and mortality, the...
Despite advances in treatment, chronic heart failure is still associated with significant morbidity ...
The failing heart has an increased metabolic demand and at the same time suffers from impaired energ...
The incidence and prevalence of heart failure have increased significantly over the past few decades...
The morbidity and mortality of coronary heart disease and of heart failure remain unacceptably high ...
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality ...
Despite significant therapeutic advances in heart failure (HF) therapy, the morbidity and mortality ...
Fatty acids are the main substrates used by mitochondria to provide myocardial energy under normal c...
AbstractThe heart is responsible for pumping blood throughout the blood vessels to the periphery by ...
Energy substrate metabolism and contractile function are tightly coupled in the heart. Within this f...
Purpose of reviewWe focus on the molecular and cellular basis of the improvement in myocardial energ...
Objectives. We will review current concepts regarding bioenergetic decline in heart failure (HF). In...
Heart failure (HF) currently affects more than 37 million people globally and is rising in prevalenc...