The subtleties of insulin treatment in patients with lipodystrophy

In the treatment of Diabetes Mellitus (DM), which develops on the basis of insulin resistance in patients with lipodystrophy (LD) often require high doses of insulin. Traditionally in practice is to gradually increase the insulin doses to achieve blood glucose normalization. The fact that high insulin doses require a larger injection volume, which causes impairment in the absorption of insulin from the subcutaneous tissue to the circulation. In this article, we discussed the clinical approach to insulin practice in the treatment of DM in patients with LD and reviewed systematically the literature