This paper proposes science-based organization design that uses construction principles and design rules to guide practitioner-academic projects. Organization science implies construction principles for creating and implementing designs. These principles serve to construct design rules that are instrumental in developing organization designs. Testing and implementing designs require pragmatic experimentation in complex, dynamic settings. The authors explore a circular design process as an example of science-based organization design. Tests of this circular process in over 30 organizations suggest that construction principles are important for creating new design rules as well as for a deeper understanding of the systems and practices create...