Optimization of basic parameters in temperature-programmed gas chromatographic separations of multi-component samples within a given time

A new procedure is introduced for the optimization of column peak capacity in a given time. The opitmization focuses on temperature-programmed operating conditions, notably the initial temperature and hold time, and the programming rate. Based conceptually upon Lagrange functions, experiments were carried out long simplex sequential and central composite design procedures. The validity of the theory was demonstrated by separations of some crude oil distillation fractions