Add to ORKGNovel protocols for whole-cell patch clamp current recordings have the potential to uniquely identify Markovmodel parameters. For the fast sodium current, which operates at very small time scales, measurement noise and amplifier imperfections can affect the recorded signal in nontrivial ways. We investigated the unique identification of the kinetical parameters of the fast sodium current from imperfect whole-cell patch clamp recordings
The Hodgkin-Huxley formalism for quantitative characterization of ionic channels is widely used in c...
Special voltage-clamp pulse protocols are given that make differential predictions for the kinetics ...
Quantitative ion channel model evaluation requires the estimation of voltage dependent rate constant...
Novel protocols for whole-cell patch clamp current recordings have the potential to uniquely identif...
Mathematical models of ion channels, which constitute indispensable components of action potential m...
We present here a maximal likelihood algorithm for estimating single-channel kinetic parameters from...
Single-channel current seems to be one of the most obvious characteristics of ion transport. But in ...
AbstractAggregated Markov models are a widely used tool to model patch clamp data measured from sing...
Markov models (MMs) represent a generalization of Hodgkin-Huxley models. They provide a versatile st...
AbstractHidden Markov models have recently been used to model single ion channel currents as recorde...
AbstractWe describe a new electrophysiological technique called nonequilibrium response spectroscopy...
AbstractPatch-clamp recording provides an unprecedented means for study of detailed kinetics of ion ...
Voltage-gated sodium channels are crucial to action potential propagation in excitable tissues. Beca...
This paper describes a theory of the kinetic analysis of patch-clamp data. We assume that channel ga...
The maximum-likelihood technique for the direct estimation of rate constants from the measured patch...
The Hodgkin-Huxley formalism for quantitative characterization of ionic channels is widely used in c...
Special voltage-clamp pulse protocols are given that make differential predictions for the kinetics ...
Quantitative ion channel model evaluation requires the estimation of voltage dependent rate constant...
Novel protocols for whole-cell patch clamp current recordings have the potential to uniquely identif...
Mathematical models of ion channels, which constitute indispensable components of action potential m...
We present here a maximal likelihood algorithm for estimating single-channel kinetic parameters from...
Single-channel current seems to be one of the most obvious characteristics of ion transport. But in ...
AbstractAggregated Markov models are a widely used tool to model patch clamp data measured from sing...
Markov models (MMs) represent a generalization of Hodgkin-Huxley models. They provide a versatile st...
AbstractHidden Markov models have recently been used to model single ion channel currents as recorde...
AbstractWe describe a new electrophysiological technique called nonequilibrium response spectroscopy...
AbstractPatch-clamp recording provides an unprecedented means for study of detailed kinetics of ion ...
Voltage-gated sodium channels are crucial to action potential propagation in excitable tissues. Beca...
This paper describes a theory of the kinetic analysis of patch-clamp data. We assume that channel ga...
The maximum-likelihood technique for the direct estimation of rate constants from the measured patch...
The Hodgkin-Huxley formalism for quantitative characterization of ionic channels is widely used in c...
Special voltage-clamp pulse protocols are given that make differential predictions for the kinetics ...
Quantitative ion channel model evaluation requires the estimation of voltage dependent rate constant...